Curcumin

Curcumin

SCHEMBL29355906

COc1cc(/C=C\C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ APP P05067 10/20 1.00
▸ MAPT P10636 9/20 1.00
▸ BACE1 P56817 5/20 1.00
▸ MMP9 P14780 4/20 1.00
▸ NFKB1 P19838 3/20 1.00
▸ CYP2D6 P10635 2/20 1.00
▸ CYP2C9 P11712 2/20 1.00
▸ TSHR P16473 2/20 1.00
▸ HSD17B10 Q99714 2/20 1.00
▸ ABCB1 P08183 2/20 1.00
▸ AKR1B1 P15121 2/20 1.00
▸ MAOA P21397 2/20 1.00
▸ MAOB P27338 2/20 1.00
▸ HDAC3 O15379 2/20 1.00
▸ HDAC1 Q13547 2/20 1.00
▸ HDAC2 Q92769 2/20 1.00
▸ HDAC6 Q9UBN7 2/20 1.00
▸ ALOX5 P09917 2/20 1.00
▸ STAT3 P40763 2/20 1.00
▸ NFKB2 Q00653 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Curcumin SCHEMBL29876635 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL2804734 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL29360171 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL29358937 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL250984 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL17629818 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL17629819 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL8336603 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL6901740 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL8440 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3400932-B1 MIXTURE OF STABILISED BIOLOGICALLY AVAILABLE CURCUMIN FOR ORODISPERSIBLE FORMULATIONS, FORMULATIONS OF BIOLOGICALLY AVAILABLE CURCUMIN, AND AN ORODISPERSIBLE TABLET WITH BIOLOGICALLY AVAILABLE CURCUMIN, AND ITS APPLICATION MCEPHARMA S R O (CZ) 2024-06-19 — — EP claimed
EP-3651804-B1 SOLUBILISATE WITH CURCUMIN, BOSWELLIA, AND XANTHOHUMOL AQUANOVA AG (DE) 2023-08-23 — — EP claimed
EP-3943071-B1 COMPOSITION COMPRISING NATURAL LIPOPHILIC COMPOUNDS, USE OF THE COMPOSITION AND METHOD FOR PREPARING THE COMPOSITION KHINIKADZE ZURAB DURMISCHCHANOWITCH (RU) 2025-06-18 — — EP disclosed
CN-120053451-A Application of pyrimethamine in preparation of antiviral preparation 中国科学院微生物研究所 2025-05-30 — — CN disclosed
WO-2023212742-A1 ACTIVE AND/OR INTELLIGENT PACKAGING MATERIALS CONTAINING RADICAL SCAVENGING LIGANDS CORNELL UNIVERSITY (US) 2023-11-02 — — WO disclosed
EP-3651804-B1 SOLUBILISATE WITH CURCUMIN, BOSWELLIA, AND XANTHOHUMOL AQUANOVA AG (DE) 2023-08-23 — — EP disclosed
CN-115919818-A Application of curcumin nano-drug in preparation of drug for treating cancer or reversing cancer chemotherapy tolerance 中山大学 2023-04-07 — — CN disclosed
CN-113975319-A Traditional Chinese medicine formula for atherosclerosis rat vascular cell apoptosis test 袁召 2022-01-28 — — CN disclosed
EP-3943071-A1 COMPOSITION COMPRISING NATURAL LIPOPHILIC COMPOUNDS, USE OF THE COMPOSITION AND METHOD FOR PREPARING THE COMPOSITION Khinikadze, Zurab Durmischchanowitch (RU) 2022-01-26 — — EP disclosed
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