Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25099252 | 0.89 | MEN1 (0.61) | RAB9AMEN1NPC1KMT2AHSP90AA1 | |
| SCHEMBL12336929 | 0.87 | POLB (0.64) | RAB9AMEN1NPC1KMT2AKDM4E | |
| SCHEMBL22912783 | 0.85 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL22963780 | 0.82 | TDP1 (0.52) | RAB9AMEN1NPC1KMT2AHSP90AA1 | |
| SCHEMBL27077574 | 0.81 | TDP1 (0.69) | RAB9AMEN1NPC1KMT2AHSP90AA1 | |
| SCHEMBL5396738 | 0.81 | NPSR1 (0.73) | RAB9AMEN1NPC1KMT2AHSP90AA1 | |
| SCHEMBL22912787 | 0.78 | KDM4E (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL29396632 | 0.78 | KDM4E (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL25318611 | 0.78 | KDM4E (0.62) | RAB9AKDM4EALDH1A1EGLN1MAPT | |
| SCHEMBL30493540 | 0.78 | KDM4E (0.62) | RAB9AKDM4EALDH1A1EGLN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230077316-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2023-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230077316-A1 | CTPS1 INHIBITORS AND USES THEREOF | CTPS1, CTPS2, ECHS1 | RAB9A 3544/4885MEN1 4328/4885NPC1 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.