SCHEMBL25100508

SCHEMBL25100508

Cc1cc(-c2ccccc2)ncc1CCc1cc(CCc2cnc(-c3ccccc3)cc2C)cc(-c2ccccc2-c2cnc(-c3ccccc3)cc2OS(=O)(=O)C(F)(F)F)c1

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LDHA P00338 1/20 0.34
FFAR1 O14842 1/20 0.32
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
DGAT1 O75907 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
CHRM5 P08912 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25100796 0.87 CHRM5 (0.39) CHRM5
SCHEMBL23956353 0.85 LDHA (0.42) LDHADGAT1KDM4EALDH1A1GAA
SCHEMBL25100918 0.84 IDO1 (0.38) LDHAFFAR1KDM4EALDH1A1GAA
SCHEMBL25100567 0.84 FFAR1 (0.35) LDHAFFAR1NR1H2NR1H3DGAT1
SCHEMBL25100950 0.83 CHRM5 (0.36) CHRM5
SCHEMBL25100530 0.81 LDHA (0.40) LDHAFFAR1KDM4EALDH1A1
SCHEMBL25100829 0.79 LDHA (0.39) LDHAFFAR1
SCHEMBL25100920 0.79 LDHA (0.41) LDHAFFAR1
SCHEMBL23956284 0.78 ALOX5AP (0.36) LDHACHRM5
SCHEMBL22915024 0.77 TOP1 (0.36) LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3752512-B1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2023-03-01 EP disclosed