SCHEMBL25100643

SCHEMBL25100643

CC(C)n1cnc2nc[nH]c(=O)c21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.47
ADORA1 P30542 1/20 0.47
ALDH1A1 P00352 4/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
POLB P06746 1/20 0.37
PNP P00491 1/20 0.34
BRD4 O60885 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
HPGD P15428 2/20 0.33
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33
TP53 P04637 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ADORA2B P29275 1/20 0.33
LMNA P02545 1/20 0.33
TSHR P16473 1/20 0.33
SLC6A4 P31645 1/20 0.33
ADRA1A P35348 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2414856 0.77 ALDH1A1 (0.47) ADORA2AADORA1ALDH1A1POLBBRD4
SCHEMBL7990063 0.77 ALDH1A1 (0.47) ADORA2AADORA1ALDH1A1POLBBRD4
Hydrochloric Acid SCHEMBL29540090 0.75 ALDH1A1 (0.45) ADORA2AADORA1ALDH1A1POLBPNP
SCHEMBL19413462 0.73 ADORA2A (0.49) ADORA2AADORA1ALDH1A1MEN1KMT2A
SCHEMBL757117 0.73 ADORA2A (0.41) ADORA2AADORA1ALDH1A1HPGD
SCHEMBL784333 0.72 ADORA2A (0.51) ADORA2AADORA1ALDH1A1MEN1KMT2A
SCHEMBL20187696 0.72 ALDH1A1 (0.42) ADORA2AADORA1ALDH1A1POLBBRD4
SCHEMBL25165828 0.71 ADORA2A (0.50) ADORA2AADORA1ALDH1A1POLBHSD17B10
SCHEMBL7046793 0.71 ALDH1A1 (0.41) ADORA2AALDH1A1POLBPNPBRD4
SCHEMBL1866524 0.70 ADORA2A (0.50) ADORA2AADORA1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023168786-A1 USE OF 1,7-DIHYDRO-6H-PURIN-6-ONE COMPOUNDS IN PREPARATION OF ANTI-PULMONARY FIBROSIS DRUG 四川大学华西医院 2023-09-14 WO disclosed
WO-2023028350-A1 THERAPEUTIC COMPOSITIONS AND RELATED METHODS BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC. (US) 2023-03-02 WO disclosed