Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2509408 | 0.79 | ADH5 (0.34) | CYP3A4CYP2D6PORCN | |
| SCHEMBL2483928 | 0.67 | SYK (0.32) | CYP3A4CYP2D6PORCN | |
| SCHEMBL2483931 | 0.67 | SYK (0.32) | CYP3A4CYP2D6PORCN | |
| SCHEMBL2498451 | 0.66 | PDE3B (0.36) | CYP3A4CYP2D6PORCN | |
| SCHEMBL2477814 | 0.66 | ROCK2 (0.39) | CYP3A4CYP2D6PORCN | |
| SCHEMBL2446909 | 0.66 | ROCK2 (0.39) | CYP3A4CYP2D6PORCN | |
| SCHEMBL2477810 | 0.66 | ROCK2 (0.39) | CYP3A4CYP2D6PORCN | |
| SCHEMBL2843972 | 0.62 | ROCK2 (0.33) | — | |
| SCHEMBL2449527 | 0.62 | ROCK2 (0.33) | — | |
| SCHEMBL2848556 | 0.61 | MAPT (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |