SCHEMBL25105563

SCHEMBL25105563

Cc1cn2cc(NC(=O)c3ccc(N4CC[C@@H](NC(=O)OC(C)(C)C)C4)c4cn(C)nc34)cc(F)c2n1

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ SMPD3 Q9NY59 5/20 0.40
▸ USP30 Q70CQ3 1/20 0.40
▸ F10 P00742 1/20 0.37
▸ SUV39H2 Q9H5I1 8/20 0.37
▸ PDE10A Q9Y233 1/20 0.36
▸ DRD2 P14416 1/20 0.35
▸ DRD3 P35462 1/20 0.35
▸ PIM1 P11309 1/20 0.35
▸ PIM3 Q86V86 1/20 0.35
▸ PIM2 Q9P1W9 1/20 0.35
▸ RPS6KB1 P23443 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31210839 1.00 SMPD3 (0.40) SMPD3USP30F10SUV39H2PDE10A
SCHEMBL25105375 0.97 USP30 (0.39) SMPD3USP30SUV39H2DRD2DRD3
SCHEMBL25105337 0.91 ATM (0.38) SMPD3USP30SUV39H2PDE10A
SCHEMBL25104157 0.90 SMPD3 (0.40) SMPD3USP30DRD2DRD3RPS6KB1
SCHEMBL25103095 0.89 SMPD3 (0.42) SMPD3DRD2DRD3
SCHEMBL25102757 0.88 SMPD3 (0.41) SMPD3RPS6KB1
SCHEMBL25102754 0.88 SMPD3 (0.41) SMPD3RPS6KB1
SCHEMBL25103694 0.88 SMPD3 (0.41) SMPD3RPS6KB1
SCHEMBL25102775 0.88 HTR1A (0.37) SMPD3DRD2DRD3
SCHEMBL25105219 0.88 SMPD3 (0.40) SMPD3DRD2DRD3RPS6KB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250154169-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. 2025-05-15 — — US disclosed
WO-2024182778-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2024-09-06 — — WO disclosed
EP-4395892-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2024-07-10 — — EP disclosed
WO-2023034812-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-03-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250154169-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 SMPD3 1630/4885USP30 3026/4885F10 2882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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