Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RHEB | Q15382 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GCGR | P47871 | 1/20 | 0.51 |
| ▸ | SCD | O00767 | 2/20 | 0.49 |
| ▸ | GUSB | P08236 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672566 | 0.88 | NPC1 (0.66) | HDAC6KDM4EALDH1A1PKN1PKN2 | |
| SCHEMBL24074323 | 0.87 | HDAC6 (0.60) | HDAC6SCDTRPV1NPBWR1 | |
| SCHEMBL13118022 | 0.86 | HDAC6 (0.68) | HDAC6KDM4EALDH1A1PKN2CYP3A4 | |
| SCHEMBL10574973 | 0.86 | PKN1 (0.52) | HDAC6KDM4EALDH1A1PKN1PKN2 | |
| Ammonia Solution, Strong SCHEMBL2446708 | 0.85 | HDAC6 (0.66) | HDAC6KDM4EALDH1A1PKN2CYP3A4 | |
| SCHEMBL5680196 | 0.85 | KDM4E (0.59) | KDM4EALDH1A1PKN1PKN2CYP1A2 | |
| SCHEMBL10573939 | 0.85 | KDM4E (0.49) | HDAC6KDM4EALDH1A1PKN1PKN2 | |
| SCHEMBL10580819 | 0.84 | KDM4E (0.48) | HDAC6KDM4EALDH1A1PKN1PKN2 | |
| SCHEMBL1610237 | 0.84 | HDAC6 (0.60) | HDAC6KDM4EALDH1A1CYP3A4HPGD | |
| SCHEMBL10580821 | 0.83 | KDM4E (0.50) | HDAC6KDM4EALDH1A1PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230065217-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. | 2023-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230065217-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | MRGPRX2, MRGPRX1, MRGPRX4 | HDAC6 2604/4885KDM4E 4479/4885ALDH1A1 4805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.