Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | NPBWR1 | P48145 | 7/20 | 0.58 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.56 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.55 |
| ▸ | RHEB | Q15382 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15245140 | 0.91 | DGAT1 (0.67) | NPBWR1DGAT1KCNH2SOAT1TRPV1 | |
| SCHEMBL30615051 | 0.86 | NPBWR1 (0.78) | NPBWR1DGAT1KCNH2MAPK13RAF1 | |
| SCHEMBL29091542 | 0.86 | NPBWR1 (0.78) | NPBWR1DGAT1KCNH2MAPK13RAF1 | |
| SCHEMBL25110163 | 0.85 | HDAC6 (0.57) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10325105 | 0.84 | NPBWR1 (0.58) | NPBWR1DGAT1KCNH2SOAT1TRPV1 | |
| SCHEMBL30343717 | 0.84 | NPBWR1 (0.59) | KDM4EALDH1A1CYP3A4HPGDHSD17B10 | |
| SCHEMBL24074323 | 0.84 | HDAC6 (0.60) | NPBWR1DGAT1KCNH2SOAT1TRPV1 | |
| SCHEMBL6325961 | 0.84 | NPBWR1 (0.59) | KDM4EALDH1A1CYP3A4HPGDHSD17B10 | |
| SCHEMBL21705325 | 0.84 | HDAC6 (0.64) | NPBWR1DGAT1KCNH2SOAT1TRPV1 | |
| SCHEMBL31027889 | 0.84 | HDAC6 (0.64) | NPBWR1DGAT1KCNH2SOAT1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620413-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098494-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-11-18 | — | — | WO | disclosed |