Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TNFSF11 | O14788 | 3/20 | 0.47 |
| ▸ | TNF | P01375 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 7/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765084 | 0.87 | LMNA (0.71) | LMNASMN1; SMN2AKR1C3AKR1C1PLK1 | |
| SCHEMBL4926276 | 0.84 | LMNA (0.74) | LMNASMN1; SMN2AKR1C3AKR1C1FABP4 | |
| SCHEMBL6764600 | 0.82 | LMNA (0.48) | LMNASMN1; SMN2AKR1C3AKR1C1PLK1 | |
| SCHEMBL6764599 | 0.82 | LMNA (0.48) | LMNASMN1; SMN2AKR1C3AKR1C1PLK1 | |
| SCHEMBL6767283 | 0.78 | MEN1 (0.52) | LMNASMN1; SMN2AKR1C3AKR1C1PLK1 | |
| SCHEMBL6767287 | 0.78 | MEN1 (0.52) | LMNASMN1; SMN2AKR1C3AKR1C1PLK1 | |
| SCHEMBL1468385 | 0.76 | AKR1C3 (0.60) | LMNASMN1; SMN2AKR1C3AKR1C1PLK1 | |
| SCHEMBL1466360 | 0.76 | AKR1C3 (0.60) | LMNASMN1; SMN2AKR1C3AKR1C1FABP4 | |
| SCHEMBL1466474 | 0.76 | AKR1C3 (0.60) | LMNASMN1; SMN2AKR1C3AKR1C1FABP4 | |
| SCHEMBL6765180 | 0.76 | LMNA (0.65) | LMNASMN1; SMN2AKR1C3AKR1C1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552887-B1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | UNIV TAIPEI MEDICAL (TW) | 2018-10-24 | — | — | EP | claimed |
| EP-2552887-B1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | UNIV TAIPEI MEDICAL (TW) | 2018-10-24 | — | — | EP | disclosed |
| US-9598364-B2 | Indolyl or indolinyl hydroxamate compounds | TAIPEI MEDICAL UNIVERSITY (TW) | 2017-03-21 | — | — | US | disclosed |
| US-20140364477-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2014-12-11 | — | — | US | disclosed |
| US-8846748-B2 | Indolyl or indolinyl hydroxamate compounds | TAIPEI MEDICAL UNIVERSITY (TW) | 2014-09-30 | — | — | US | disclosed |
| EP-2552887-A2 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | Taipei Medical University (TW) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011126821-A2 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2011-10-13 | — | — | WO | disclosed |
| US-20110245315-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245315-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | IDH3A, IDH2, IDH3B | LMNA 3572/4885SMN1; SMN2 3613/4885AKR1C3 733/4885 |
| US-20140364477-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | IDH3A, IDH2, IDH3B | LMNA 3572/4885SMN1; SMN2 3613/4885AKR1C3 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.