Fenbufen

Fenbufen

SCHEMBL25117

O=C(O)CCC(=O)c1ccc(-c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 1.00
FFAR1 O14842 2/20 1.00
LMNA P02545 1/20 1.00
CYP1A2 P05177 1/20 1.00
RAB9A P51151 1/20 1.00
HIF1A Q16665 1/20 1.00
NR4A2 P43354 1/20 0.76
L3MBTL1 Q9Y468 3/20 0.69
HPGD P15428 1/20 0.69
ALDH1A1 P00352 2/20 0.68
GAA P10253 1/20 0.68
CYP2C19 P33261 1/20 0.68
PTPN1 P18031 1/20 0.62
GSK3B P49841 1/20 0.62
KMT2A Q03164 1/20 0.62
MAPT P10636 1/20 0.62
ERCC5 P28715 1/20 0.58
FEN1 P39748 1/20 0.58
HAO1 Q9UJM8 1/20 0.58
HDAC1 Q13547 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenbufen SCHEMBL11329267 1.00 SMN1; SMN2 (1.00) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
Fenbufen SCHEMBL11393779 0.98 SMN1; SMN2 (0.96) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
SCHEMBL10884944 0.94 SMN1; SMN2 (0.88) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
SCHEMBL8534233 0.91 SMN1; SMN2 (0.84) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
Fenbufen SCHEMBL8199650 0.89 FFAR1 (0.80) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
SCHEMBL3809685 0.88 SMN1; SMN2 (0.79) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
SCHEMBL354105 0.87 NR4A2 (1.00) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
SCHEMBL10353454 0.87 NR4A2 (0.81) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
SCHEMBL3383104 0.86 HDAC8 (0.79) SMN1; SMN2FFAR1LMNACYP1A2RAB9A
SCHEMBL3381623 0.86 HDAC8 (0.79) SMN1; SMN2FFAR1LMNACYP1A2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 32180 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075406-A Ensifen pharmaceutical composition, preparation method and application thereof 2026-05-26 CN claimed
CN-122016582-A Particle size detection method of enkephalin 江苏德迈药业有限公司 2026-05-12 CN claimed
EP-4724049-A1 MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF Catalent Ontario Limited (CA) 2026-04-15 EP claimed
US-12569451-B2 Bio-inspired tissue-adhesive hydrogel patch and uses thereof Cellartgen Inc. (KR) 2026-03-10 US claimed
US-20260027337-A1 TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS MORNINGSIDE VENTURE INVESTMENTS LTD (MC) 2026-01-29 US claimed
US-12515030-B2 Transdermal drug delivery devices and methods MORNINGSIDE VENTURE INVESTMENTS LIMITED (MC) 2026-01-06 US claimed
US-20260000741-A1 METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE ACERAGEN INC (US) 2026-01-01 US claimed
EP-3699174-B1 COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME ILAB (KR) 2025-11-12 EP claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
CN-120117987-A Arylalkanoic acid phloroglucinol ester compound, preparation method and application thereof 南华大学 2025-06-10 CN claimed
EP-0114886-A1 IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE. SUNSHINE ABRAHAM (US) 1984-08-08 EP claimed
WO-1984000490-A1 IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME SUNSHINE ABRAHAM 1984-02-16 WO claimed
US-4390545-A FENBUFEN AND B-OXO (OR) IMINO THIOPHENEPROPIONITRILES AMERICAN CYANAMID COMPANY (US) 1983-06-28 US claimed
EP-0012621-B1 ANALGESIC COMPOSITION COMPRISING ACETAMINOPHEN AS A POTENTIATING AGENT McNeilab, Inc. (US) 1983-06-08 EP claimed
EP-0072462-A2 Pharmaceutical preparations Toko Yakuhin Industry Co., Ltd. (JP) 1983-02-23 EP claimed
EP-0034270-A1 Combinations of agents which give enhanced anti-inflammatory activity AMERICAN CYANAMID COMPANY (US) 1981-08-26 EP claimed
US-4233317-A 3-(4-BIPHENYLYLCARBONYL)PROPIONIC ACID AND ACETAMINOPHEN MCNEILAB, INC. (US) 1980-11-11 US claimed
US-4219668-A ANTITHROMBOTIC AND ANTIINFLAMMATORY AGENTS AMERICAN CYANAMID COMPANY (US) 1980-08-26 US claimed
EP-0012621-A1 Analgesic composition comprising acetaminophen as a potentiating agent McNeilab, Inc. (US) 1980-06-25 EP claimed
US-3966960-A 3-(4-Biphenylcarbonyl)propionic acid as an inhibitor of platelet aggregation AMERICAN CYANAMID COMPANY (US) 1976-06-29 US claimed