Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 9/20 | 0.70 |
| ▸ | GNAI3 | P08754 | 8/20 | 0.61 |
| ▸ | GNAI1 | P63096 | 8/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25444591 | 0.96 | GNAO1 (0.70) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| SCHEMBL25654123 | 0.96 | GNAO1 (0.65) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL30330575 | 0.94 | GNAO1 (0.73) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| Fluoride SCHEMBL29252689 | 0.94 | GNAO1 (0.68) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| Fluoride SCHEMBL29252484 | 0.94 | GNAO1 (0.68) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| Hydrochloric Acid SCHEMBL30330489 | 0.94 | GNAO1 (0.73) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| Fluoride SCHEMBL29252667 | 0.94 | GNAO1 (0.68) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| Fluoride SCHEMBL29252449 | 0.94 | GNAO1 (0.68) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| SCHEMBL17424035 | 0.94 | GNAO1 (0.67) | GNAO1GNAI3GNAI1KCNH2CHRM2 | |
| SCHEMBL7733753 | 0.92 | GNAO1 (0.70) | GNAO1GNAI3GNAI1KCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230110648-A1 | ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR THE DEGRADATION OF EGFR | C4 THERAPEUTICS, INC. (US) | 2023-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230110648-A1 | ISOINDOLINONE AND INDAZOLE COMPOUNDS FOR THE DEGRADATION OF EGFR | EGFR, ERBB2, ERBB3 | GNAO1 3502/4885GNAI3 1007/4885GNAI1 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.