Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805635 | 0.93 | KDM4E (0.38) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL18714193 | 0.93 | KDM4E (0.38) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3676593 | 0.93 | KDM4E (0.38) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3680032 | 0.93 | KDM4E (0.38) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL75457 | 0.93 | KDM4E (0.38) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL19380643 | 0.93 | KDM4E (0.38) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL118602 | 0.80 | KDM4E (0.39) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL13324800 | 0.80 | KDM4E (0.41) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8402175 | 0.77 | KDM4E (0.36) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL18713286 | 0.77 | KDM4E (0.36) | KDM4EALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8663904-B2 | Norbornene-type polymers, compositions thereof and lithographic process using such compositions | PROMERUS, LLC (US) | 2014-03-04 | — | — | US | disclosed |
| US-20130323644-A1 | NORBORNENE-TYPE POLYMERS, COMPOSITIONS THEREOF AND LITHOGRAPHIC PROCESS USING SUCH COMPOSITIONS | PROMERUS, LLC (US) | 2013-12-05 | — | — | US | disclosed |
| US-8541523-B2 | Norbornene-type polymers, compositions thereof and lithographic process using such compositions | PROMERUS, LLC (US) | 2013-09-24 | — | — | US | disclosed |
| US-20110244400-A1 | Norbornene-Type Polymers, Compositions Thereof and Lithographic Process Using Such Compositions | PROMERUS LLC (US) | 2011-10-06 | — | — | US | disclosed |