Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923920 | 0.75 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1NSD2CASP6G6PD | |
| SCHEMBL27163581 | 0.74 | KDM4E (0.35) | HSP90AA1HSP90AB1AXLPRKCIKDM4E | |
| SCHEMBL3305107 | 0.73 | NQO2 (0.39) | ALOX5APFEN1NQO2CA2CA4 | |
| SCHEMBL22233797 | 0.73 | KDM4E (0.39) | HSP90AA1AXLPRKCIKDM4EMEN1 | |
| SCHEMBL24010300 | 0.72 | KDM4E (0.40) | HSP90AA1G6PDDYRK1AKDM4EMEN1 | |
| SCHEMBL6599333 | 0.72 | NQO2 (0.38) | NQO2CA2CA4NSD2CASP6 | |
| SCHEMBL24009363 | 0.71 | PDE2A (0.42) | HSP90AA1HSP90AB1G6PDDYRK1AKDM4E | |
| SCHEMBL1878775 | 0.71 | KDM4E (0.37) | HSP90AA1HSP90AB1AXLPRKCIKDM4E | |
| SCHEMBL25130340 | 0.70 | MAPT (0.51) | KDM4EALDH1A1TP53LMNAMAPT | |
| SCHEMBL30666114 | 0.70 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1AXLPRKCIG6PD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023051628-A1 | SOS1 INHIBITORS HAVING PYRIDO SIX-MEMBERED RING STRUCTURE | 上海海和药物研究开发股份有限公司 | 2023-04-06 | — | — | WO | disclosed |