Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 5/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | TTK | P33981 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25130641 | 0.85 | AXL (0.42) | AXLMAPK1PIM1FGFR3KDR | |
| SCHEMBL31284949 | 0.75 | AXL (0.48) | AXLMAPK1FGFR3KDRCDK2 | |
| SCHEMBL25130613 | 0.71 | GRM4 (0.34) | — | |
| SCHEMBL20732984 | 0.69 | ACVR1 (0.59) | AXL | |
| SCHEMBL21404406 | 0.69 | AXL (0.42) | AXLMAPK1PIM1ADORA2ACCNB2 | |
| SCHEMBL30878037 | 0.69 | AXL (0.42) | AXLMAPK1PIM1ADORA2ACCNB2 | |
| SCHEMBL31107039 | 0.68 | DYRK1A (0.46) | FGFR3KDRTTKAURKAAURKB | |
| SCHEMBL14947690 | 0.68 | DYRK1A (0.46) | FGFR3KDRTTKAURKAAURKB | |
| SCHEMBL25130855 | 0.68 | CSNK2A1 (0.34) | — | |
| SCHEMBL19965493 | 0.68 | PIM1 (0.72) | AXLMAPK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023051628-A1 | SOS1 INHIBITORS HAVING PYRIDO SIX-MEMBERED RING STRUCTURE | 上海海和药物研究开发股份有限公司 | 2023-04-06 | — | — | WO | disclosed |