Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.32 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27167385 | 0.83 | CSNK2A1 (0.35) | CSNK2A1HIPK2NSD2CASP6APAF1 | |
| SCHEMBL25130861 | 0.81 | KDM4E (0.35) | G6PDCCR4SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL29923740 | 0.79 | CSNK2A1 (0.33) | CSNK2A1HIPK2NSD2CASP6APAF1 | |
| SCHEMBL24916320 | 0.79 | CSNK2A1 (0.33) | CSNK2A1HIPK2NSD2CASP6APAF1 | |
| SCHEMBL25130613 | 0.79 | GRM4 (0.34) | APAF1TDP2CASP3SENP8SENP7 | |
| SCHEMBL160724 | 0.74 | NR1I3 (0.41) | KDM4ETP53HSP90AA1PDCD1CD274 | |
| SCHEMBL20292984 | 0.73 | NSD2 (0.40) | NSD2CASP6G6PDAPAF1TDP2 | |
| SCHEMBL26639901 | 0.72 | ALDH1A1 (0.43) | CCR4SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL31729196 | 0.70 | CCR4 (0.33) | CSNK2A1HIPK2CCR4SMN1; SMN2KDM4E | |
| SCHEMBL30657478 | 0.70 | MEN1 (0.34) | CCR4KDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023051628-A1 | SOS1 INHIBITORS HAVING PYRIDO SIX-MEMBERED RING STRUCTURE | 上海海和药物研究开发股份有限公司 | 2023-04-06 | — | — | WO | disclosed |