Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 3/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30791048 | 0.87 | ACMSD (0.44) | SLC1A3SLC1A2SLC1A1ACMSDESR1 | |
| SCHEMBL20681207 | 0.87 | ACMSD (0.44) | SLC1A3SLC1A2SLC1A1ACMSDESR1 | |
| SCHEMBL25139030 | 0.85 | HSP90AA1 (0.40) | — | |
| SCHEMBL20938321 | 0.81 | MCL1 (0.39) | ICMTCA1CA2 | |
| SCHEMBL20681162 | 0.80 | MTNR1A (0.38) | PTGER3ACMSDAKR1C3AKR1C2SLC6A2 | |
| SCHEMBL25067147 | 0.80 | AKR1C3 (0.38) | PTGER3EPHX1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL30791033 | 0.80 | MTNR1A (0.38) | PTGER3ACMSDAKR1C3AKR1C2SLC6A2 | |
| SCHEMBL25138977 | 0.78 | IKBKB (0.43) | ACMSD | |
| SCHEMBL25139155 | 0.78 | ESR1 (0.43) | ACMSDESR1ESR2ALOX5CA1 | |
| SCHEMBL25139100 | 0.77 | PPARG (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658538-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-04-19 | — | — | EP | disclosed |