Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 9/20 | 1.00 |
| ▸ | USP8 | P40818 | 9/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.57 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.57 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25140490 | 0.84 | USP2 (1.00) | USP2USP8NPC1KMT2AMEN1 | |
| SCHEMBL25140484 | 0.83 | USP8 (1.00) | USP2USP8NPC1KLF5KMT2A | |
| SCHEMBL25140489 | 0.82 | USP2 (1.00) | USP2USP8NPC1KLF5KMT2A | |
| SCHEMBL31134957 | 0.80 | USP2 (0.71) | USP2USP8NPC1KLF5KMT2A | |
| SCHEMBL4918858 | 0.77 | RAB9A (0.76) | NPC1KLF5KMT2AMEN1KDM4E | |
| SCHEMBL6769684 | 0.77 | NPC1 (1.00) | USP2USP8NPC1KLF5KMT2A | |
| SCHEMBL14808194 | 0.73 | CNR1 (1.00) | NPC1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL5955962 | 0.73 | USP2 (0.57) | USP2USP8KMT2AMEN1ALDH1A1 | |
| SCHEMBL4916511 | 0.72 | NPC1 (1.00) | NPC1KLF5KMT2AMEN1KDM4E | |
| SCHEMBL31134932 | 0.71 | USP2 (0.63) | USP2USP8NPC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023061051-A1 | SULFAMIDE USP8 INHIBITOR AND USE THEREOF | 中国药科大学 | 2023-04-20 | — | — | WO | disclosed |