Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 1.00 |
| ▸ | KLF5 | Q13887 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.76 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.74 |
| ▸ | FES | P07332 | 1/20 | 0.74 |
| ▸ | PIM1 | P11309 | 1/20 | 0.74 |
| ▸ | CDK2 | P24941 | 1/20 | 0.74 |
| ▸ | GSK3A | P49840 | 1/20 | 0.74 |
| ▸ | GSK3B | P49841 | 1/20 | 0.74 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.74 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.74 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.74 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.74 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.74 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766057 | 0.87 | NPC1 (1.00) | NPC1KLF5RAB9AL3MBTL1PKM | |
| SCHEMBL4920242 | 0.86 | RAB9A (0.79) | NPC1KLF5RAB9AL3MBTL1PKM | |
| SCHEMBL4910026 | 0.82 | NPC1 (1.00) | NPC1KLF5RAB9AL3MBTL1MAPT | |
| SCHEMBL2624629 | 0.81 | MAPT (0.71) | NPC1KLF5RAB9AMAPTLMNA | |
| SCHEMBL4916511 | 0.81 | NPC1 (1.00) | NPC1KLF5RAB9AL3MBTL1MAPT | |
| SCHEMBL30930 | 0.81 | NPC1 (0.73) | NPC1KLF5RAB9APKMDCLK1 | |
| SCHEMBL4916732 | 0.81 | NPC1 (0.74) | NPC1KLF5RAB9AL3MBTL1PKM | |
| SCHEMBL17287756 | 0.80 | NPC1 (0.67) | NPC1KLF5RAB9AL3MBTL1PKM | |
| SCHEMBL17287754 | 0.80 | NPC1 (0.67) | NPC1KLF5RAB9AL3MBTL1PKM | |
| SCHEMBL13568288 | 0.80 | NPC1 (0.82) | NPC1KLF5RAB9AL3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720344-B2 | BINDING TO NUCLEAR RECEPTOR PROTEINS; STIMULATING BMP-2 PROMOTER ACTIVITY | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2004-04-13 | — | — | US | disclosed |
| US-20030119791-A1 | Methods and compositions for stimulating osteoblast proliferation or treating malignant cell proliferation and methods for selecting osteoblast proliferation stimulants | KERWIN SEAN M (US) | 2003-06-26 | — | — | US | disclosed |
| EP-0912549-A4 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | UNIV TEXAS (US) | 2002-01-02 | — | — | EP | disclosed |
| CN-1226245-A | Compound with pharmacological activity, preparation method and application thereof | UNIV TEXAS (US) | 1999-08-18 | — | — | CN | disclosed |
| EP-0912549-A1 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997048694-A1 | COMPOUNDS AND METHODS FOR PROVIDING PHARMACOLOGICALLY ACTIVE PREPARATIONS AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119791-A1 | Methods and compositions for stimulating osteoblast proliferation or treating malignant cell proliferation and methods for selecting osteoblast proliferation stimulants | MKI67, HGF, AREG | NPC1 3040/4885KLF5 351/4885RAB9A 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.