Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 15/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2519693 | 0.82 | IDO1 (0.55) | IDO1LMNANOS1MAPTNPC1 | |
| SCHEMBL2517638 | 0.80 | IDO1 (0.52) | IDO1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2516354 | 0.77 | HTR3E (0.53) | IDO1SIGMAR1KDM4EMAPTNPC1 | |
| SCHEMBL2513748 | 0.76 | IDO1 (0.49) | IDO1LMNANOS1MAPTSMN1; SMN2 | |
| SCHEMBL1832612 | 0.76 | HTR3E (0.56) | IDO1GRIN2BLMNANOS1KDM4E | |
| SCHEMBL2521525 | 0.76 | IDO1 (0.46) | IDO1LMNANOS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6046550 | 0.73 | IDO1 (1.00) | IDO1LMNAMAPTHPGDHTT | |
| SCHEMBL8400992 | 0.73 | GRIN2D (0.64) | IDO1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2518465 | 0.72 | NOS2 (0.49) | IDO1LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL2521619 | 0.72 | IDO1 (0.42) | IDO1LMNASMN1; SMN2NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034953-B2 | Modulators of indoleamine 2,3-dioxygenase and methods of using the same | INCYTE CORPORATION (US) | 2011-10-11 | — | — | US | disclosed |