Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029004 | 0.89 | HRH4 (0.34) | HRH3HRH4SLC6A4 | |
| SCHEMBL9031824 | 0.83 | HRH3 (0.50) | HRH3HRH4SLC6A4CACNA1H | |
| SCHEMBL25936006 | 0.76 | CACNA1H (0.51) | HRH3HRH4SLC6A4CACNA1HGBA1 | |
| SCHEMBL21607006 | 0.71 | GBA1 (0.52) | HRH3HRH4SLC6A4CACNA1HGBA1 | |
| SCHEMBL1299331 | 0.69 | HTR2C (0.41) | HRH3HRH4 | |
| SCHEMBL24228552 | 0.69 | HRH3 (0.44) | HRH3HRH4SLC6A4CACNA1HGBA1 | |
| SCHEMBL1299385 | 0.68 | HRH3 (0.46) | HRH3HRH4SLC6A4CACNA1HGBA1 | |
| SCHEMBL20088429 | 0.68 | CACNA1H (0.64) | CACNA1HCACNA1GKCNH2 | |
| Hydrochloric Acid SCHEMBL22468912 | 0.67 | HTR2B (0.45) | HRH3HRH4SLC6A4CACNA1HGBA1 | |
| Hydrochloric Acid SCHEMBL26090375 | 0.67 | HTR2B (0.45) | HRH3HRH4SLC6A4CACNA1HGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379524-A1 | SEROTONIN 5-HT2B RECEPTOR INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010080357-A1 | SEROTONIN 5-HT2B RECEPTOR INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |