Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 3/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30720855 | 0.78 | TLR7 (0.35) | CACNA1HCACNA1GCACNA1C | |
| SCHEMBL2514697 | 0.76 | HRH3 (0.47) | CACNA1HCACNA1GHRH3HRH4SLC6A4 | |
| SCHEMBL12798680 | 0.72 | HTR2C (0.46) | HRH3HRH4APP | |
| SCHEMBL27324678 | 0.72 | ADRB1 (0.40) | HRH3 | |
| Hydrochloric Acid SCHEMBL16992579 | 0.71 | HTR2C (0.47) | HRH3HRH4APP | |
| SCHEMBL25145833 | 0.71 | CACNA1H (0.44) | CACNA1HCACNA1GHRH3HRH4SLC6A4 | |
| SCHEMBL25145562 | 0.70 | CACNA1H (0.49) | CACNA1HCACNA1GHRH3HRH4SLC6A4 | |
| SCHEMBL25145641 | 0.70 | ADRB1 (0.48) | CACNA1HCACNA1GHRH3HRH4GBA1 | |
| SCHEMBL25146233 | 0.69 | CACNA1H (0.42) | CACNA1HCACNA1GHRH3HRH4GBA1 | |
| SCHEMBL25145915 | 0.69 | CACNA1H (0.45) | CACNA1HCACNA1GHRH3HRH4SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024088922-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MONOACYLGLYCEROL LIPASE (MAGL) | F. HOFFMANN-LA ROCHE AG (CH) | 2024-05-02 | — | — | WO | disclosed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | disclosed |