Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 6/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 6/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31660328 | 1.00 | P2RX3 (0.32) | P2RX3P2RX2PLK1PDE10AKDM4E | |
| SCHEMBL25148195 | 0.86 | GRIN2D (0.31) | PDE10A | |
| SCHEMBL30332146 | 0.86 | GRIN2D (0.31) | PDE10A | |
| SCHEMBL25148366 | 0.85 | GRIN2D (0.32) | P2RX3P2RX2PLK1PDE10AKDM4E | |
| SCHEMBL31659721 | 0.85 | GRIN2D (0.32) | P2RX3P2RX2PLK1PDE10AKDM4E | |
| SCHEMBL25148403 | 0.84 | JAK2 (0.35) | P2RX3P2RX2PLK1PDE10A | |
| SCHEMBL31659875 | 0.84 | JAK2 (0.35) | P2RX3P2RX2PLK1PDE10A | |
| SCHEMBL31659632 | 0.83 | P2RX3 (0.32) | P2RX3P2RX2PLK1PDE10A | |
| SCHEMBL25148371 | 0.83 | P2RX3 (0.32) | P2RX3P2RX2PLK1PDE10A | |
| SCHEMBL25153188 | 0.83 | KDM4E (0.35) | P2RX3P2RX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064585-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | VANDERBILT UNIVERSITY (US) | 2023-04-20 | — | — | WO | disclosed |