Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25148721 | 0.79 | LMNA (0.47) | MEN1KMT2ALMNASMN1; SMN2JAK2 | |
| SCHEMBL25149422 | 0.79 | LMNA (0.47) | MEN1KMT2ALMNASMN1; SMN2JAK2 | |
| SCHEMBL25148716 | 0.79 | LMNA (0.47) | MEN1KMT2ALMNASMN1; SMN2JAK2 | |
| SCHEMBL31229541 | 0.78 | LMNA (0.40) | MEN1KMT2ALMNASMN1; SMN2JAK2 | |
| SCHEMBL25149416 | 0.77 | MEN1 (0.53) | MEN1KMT2ALMNASMN1; SMN2JAK2 | |
| SCHEMBL31422934 | 0.75 | MEN1 (0.41) | MEN1KMT2ALMNASMN1; SMN2JAK2 | |
| SCHEMBL31273432 | 0.74 | LMNA (0.42) | MEN1KMT2ALMNASMN1; SMN2JAK2 | |
| SCHEMBL31273506 | 0.74 | LMNA (0.42) | MEN1KMT2ALMNASMN1; SMN2JAK2 | |
| SCHEMBL30364979 | 0.74 | KDM4E (0.43) | POLBCA12CA1CA2CA3 | |
| SCHEMBL31423098 | 0.73 | LMNA (0.39) | MEN1KMT2ALMNASMN1; SMN2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |