Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11956429 | 1.00 | SPHK1 (0.48) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL10223487 | 0.87 | SPHK1 (0.47) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL10272352 | 0.85 | SPHK1 (0.54) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL9752336 | 0.85 | SPHK1 (0.51) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL14314018 | 0.85 | SPHK1 (0.54) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL10272353 | 0.85 | SPHK1 (0.54) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL1833725 | 0.84 | SPHK1 (0.49) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL1833726 | 0.84 | SPHK1 (0.49) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL6979603 | 0.84 | SPHK1 (0.49) | SPHK1BRD4CHRM2CHRM1CHRM3 | |
| SCHEMBL11968694 | 0.84 | SPHK1 (0.45) | SPHK1BRD4CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |