Sugi Predict

Sugi Predict / Compounds / SCHEMBL1833726

SCHEMBL1833726

SCHEMBL1833726

C#CC1COC(C)(C)N1C(=O)OC(C)(C)C

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ SPHK1 Q9NYA1 1/20 0.49
▸ BRD4 O60885 1/20 0.38
▸ CHRM2 P08172 1/20 0.36
▸ CHRM1 P11229 1/20 0.36
▸ CHRM3 P20309 1/20 0.36
▸ USP2 O75604 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ RECQL P46063 1/20 0.34
▸ HSD11B2 P80365 1/20 0.33
▸ HCRTR2 O43614 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.32
▸ CTSK P43235 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6979603 1.00 SPHK1 (0.49) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL1833725 1.00 SPHK1 (0.49) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL25148798 0.84 SPHK1 (0.48) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL11956429 0.84 SPHK1 (0.48) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL9752336 0.83 SPHK1 (0.51) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL10223487 0.83 SPHK1 (0.47) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL10272352 0.81 SPHK1 (0.54) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL14314018 0.81 SPHK1 (0.54) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL10272353 0.81 SPHK1 (0.54) SPHK1BRD4CHRM2CHRM1CHRM3
SCHEMBL11968694 0.80 SPHK1 (0.45) SPHK1BRD4CHRM2CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4733305-A2 PYRROLE COMPOUNDS Aligos Therapeutics, Inc. (US) 2026-04-29 — — EP disclosed
US-12599582-B2 Pyrrole compounds ALIGOS THERAPEUTICS, INC. (US) 2026-04-14 — — US disclosed
EP-3947349-B1 PYRROLE COMPOUNDS ALIGOS THERAPEUTICS INC (US) 2026-03-11 — — EP disclosed
US-20240425517-A1 NOVEL COMPOUND FOR DEGRADATION OF TARGET PROTEIN OR POLYPEPTIDE BY POLYUBIQUITINATION PRAZER THERAPEUTICS INC. (KR) 2024-12-26 — — US disclosed
EP-4450490-A1 NOVEL COMPOUND FOR DEGRADING TARGET PROTEIN OR POLYPEPTIDE BY USING POLYUBIQUITINATION Prazer Therapeutics Inc. (KR) 2024-10-23 — — EP disclosed
CN-118382620-A Novel compounds for degrading target proteins or polypeptides by multiple ubiquitination 普瑞泽治疗公司 2024-07-23 — — CN disclosed
US-20230390242-A1 PYRROLE COMPOUNDS ALIGOS THERAPEUTICS, INC. 2023-12-07 — — US disclosed
US-11771680-B2 Pyrrole compounds ALIGOS THERAPEUTICS, INC. (US) 2023-10-03 — — US disclosed
US-11771680-B2 Pyrrole compounds ALIGOS THERAPEUTICS, INC. (US) 2023-10-03 — — US disclosed
US-11771680-B2 Pyrrole compounds ALIGOS THERAPEUTICS, INC. (US) 2023-10-03 — — US disclosed
EP-2321287-A1 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES F. Hoffmann-La Roche AG (CH) 2011-05-18 — — EP disclosed
US-20100120864-A1 2-AMINOOXAZOLINES AS TAAR1 LIGANDS GALLEY GUIDO 2010-05-13 — — US disclosed
US-20100120864-A1 2-AMINOOXAZOLINES AS TAAR1 LIGANDS GALLEY GUIDO 2010-05-13 — — US disclosed
US-20100041686-A1 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES HOFFMANN-LA ROCHE, INC. 2010-02-18 — — US disclosed
US-20100029589-A1 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES HOFFMANN-LA ROCHE INC. 2010-02-04 — — US disclosed
WO-2010010014-A1 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2010-01-28 — — WO disclosed
US-20080261920-A1 2-Aminooxazolines as TAAR1 ligands F. HOFFMANN-LA ROCHE AG (CH) 2008-10-23 — — US disclosed
US-20080261920-A1 2-Aminooxazolines as TAAR1 ligands F. HOFFMANN-LA ROCHE AG (CH) 2008-10-23 — — US disclosed
WO-2008092785-A1 NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2008-08-07 — — WO disclosed
CN-1138773-C 4-alkenyl (and alkynyl) oxindoles as inhibitors of cell cycle protein dependent kinases, in particular CDK2 - 2004-02-18 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230390242-A1 PYRROLE COMPOUNDS PKD1, ADCYAP1R1, PYCR1 SPHK1 537/4885BRD4 1834/4885CHRM2 4748/4885
US-20100029589-A1 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES NPY5R, NPY1R, NPY4R SPHK1 2843/4885BRD4 2047/4885CHRM2 600/4885
US-20100120864-A1 2-AMINOOXAZOLINES AS TAAR1 LIGANDS TAAR1, TAAR5, NPY2R SPHK1 1971/4885BRD4 1824/4885CHRM2 283/4885
US-20240425517-A1 NOVEL COMPOUND FOR DEGRADATION OF TARGET PROTEIN OR POLYPEPTIDE BY POLYUBIQUITINATION ADRM1, SUMO1, SUMO2 SPHK1 4773/4885BRD4 441/4885CHRM2 4140/4885
US-12599582-B2 Pyrrole compounds PEF1, CYP4F8, CYP2C19 SPHK1 2817/4885BRD4 4152/4885CHRM2 4197/4885
US-11771680-B2 Pyrrole compounds PKD1, ADCYAP1R1, PYCR1 SPHK1 537/4885BRD4 1834/4885CHRM2 4748/4885
US-20100041686-A1 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES NPY5R, NPY1R, NPY4R SPHK1 2843/4885BRD4 2047/4885CHRM2 600/4885
US-20080261920-A1 2-Aminooxazolines as TAAR1 ligands TAAR1, TAAR5, NPY2R SPHK1 1971/4885BRD4 1824/4885CHRM2 283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.