Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30364712 | 1.00 | KDM4E (0.48) | KDM4EDHODHALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3752977 | 0.84 | SLC6A3 (0.46) | KDM4EMAPTSMN1; SMN2PLA2G2AKEAP1 | |
| SCHEMBL25148790 | 0.83 | PDCD1 (0.52) | KDM4EDHODHALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30185133 | 0.81 | SMN1; SMN2 (0.50) | KDM4EDHODHALDH1A1SMN1; SMN2PLA2G2A | |
| SCHEMBL24984437 | 0.81 | SMN1; SMN2 (0.50) | KDM4EDHODHALDH1A1SMN1; SMN2PLA2G2A | |
| SCHEMBL18817157 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1MAPTSMN1; SMN2PLA2G2A | |
| SCHEMBL114292 | 0.79 | KEAP1 (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2KEAP1 | |
| SCHEMBL31459616 | 0.79 | KEAP1 (0.62) | KDM4EALDH1A1MAPTSMN1; SMN2PLA2G2A | |
| SCHEMBL113592 | 0.79 | KEAP1 (0.62) | KDM4EALDH1A1MAPTSMN1; SMN2PLA2G2A | |
| SCHEMBL14923420 | 0.78 | KDM4E (0.54) | KDM4EALDH1A1MAPTSMN1; SMN2PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |