Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL964276 | 0.79 | PSEN1 (0.95) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2515341 | 0.76 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL964682 | 0.69 | ACHE (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL136503 | 0.67 | PSEN1 (0.76) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2256419 | 0.64 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4854918 | 0.64 | CHEK1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21886900 | 0.64 | RIPK1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL238032 | 0.64 | POLB (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15062311 | 0.63 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2275154 | 0.62 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379553-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2011-10-26 | — | — | EP | claimed |
| WO-2010083141-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-22 | — | — | WO | claimed |