Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029896 | 0.73 | PDE10A (0.38) | PDE10AMEN1KMT2AMAPT | |
| SCHEMBL11405556 | 0.70 | CYP2D6 (0.41) | MEN1KMT2ATSHR | |
| SCHEMBL31213551 | 0.70 | POLB (0.43) | MEN1KMT2AMAPTTSHR | |
| SCHEMBL28002004 | 0.70 | PDE10A (0.78) | PDE10AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL12066225 | 0.69 | PDE10A (1.00) | PDE10AMEN1KMT2AMAPT | |
| SCHEMBL2515397 | 0.67 | KDM4E (0.47) | HTR1ADRD4MEN1KMT2AMAPT | |
| SCHEMBL8408826 | 0.66 | PDE10A (0.77) | PDE10AMEN1KMT2AMAPT | |
| SCHEMBL7317281 | 0.66 | PDE10A (0.77) | PDE10AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL12471341 | 0.66 | PDE10A (0.77) | PDE10AMEN1KMT2AMAPT | |
| SCHEMBL5659096 | 0.66 | PDE10A (0.65) | PDE10AHTR1AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114948-B1 | INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBVIE INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8030047-B2 | Active truncated form of the RNA polymerase of flavivirus | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS (FR) | 2011-10-04 | — | — | US | disclosed |
| US-20100267113-A1 | ACTIVE TRUNCATED FORM OF THE RNA POLYMERASE OF FLAVIVIRUS | CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-10-21 | — | — | US | disclosed |
| US-20090221795-A1 | ACTIVE TRUNCATED FORM OF THE RNA POLYMERASE OF FLAVIVIRUS | CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-09-03 | — | — | US | disclosed |
| US-7459297-B2 | Active truncated form of the RNA polymerase of flavivirus | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS (FR) | 2008-12-02 | — | — | US | disclosed |
| US-20050048472-A1 | Active truncated form of the RNA polymerase of flavivirus | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS (FR) | 2005-03-03 | — | — | US | disclosed |