Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2515395 | 0.85 | ATG4B (0.42) | KDM4EHSP90AA1HSP90AB1ALDH1A1POLB | |
| SCHEMBL9837446 | 0.73 | KDM4E (0.39) | KDM4EHSP90AA1HSP90AB1ALDH1A1POLB | |
| SCHEMBL31213551 | 0.70 | POLB (0.43) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL8514176 | 0.68 | KDM4E (0.60) | KDM4EHSP90AA1HSP90AB1ALDH1A1POLB | |
| SCHEMBL11775105 | 0.67 | KDM4E (0.69) | KDM4EHSP90AA1HSP90AB1ALDH1A1POLB | |
| SCHEMBL2515402 | 0.67 | PDE10A (0.49) | MAPTHTR1ADRD4MEN1KMT2A | |
| SCHEMBL28597354 | 0.66 | ALDH1A1 (0.54) | KDM4EHSP90AA1HSP90AB1ALDH1A1POLB | |
| SCHEMBL5508940 | 0.66 | POLB (0.60) | ALDH1A1POLBGAALMNAMEN1 | |
| SCHEMBL29432901 | 0.65 | KDM4E (0.69) | KDM4EHSP90AA1HSP90AB1RAB9ANPC1 | |
| SCHEMBL2562392 | 0.65 | POLB (0.51) | ALDH1A1POLBGAAMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114948-B1 | INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBVIE INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8030047-B2 | Active truncated form of the RNA polymerase of flavivirus | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS (FR) | 2011-10-04 | — | — | US | disclosed |
| US-20100267113-A1 | ACTIVE TRUNCATED FORM OF THE RNA POLYMERASE OF FLAVIVIRUS | CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-10-21 | — | — | US | disclosed |
| US-20090221795-A1 | ACTIVE TRUNCATED FORM OF THE RNA POLYMERASE OF FLAVIVIRUS | CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-09-03 | — | — | US | disclosed |
| US-7459297-B2 | Active truncated form of the RNA polymerase of flavivirus | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS (FR) | 2008-12-02 | — | — | US | disclosed |
| US-20050048472-A1 | Active truncated form of the RNA polymerase of flavivirus | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS (FR) | 2005-03-03 | — | — | US | disclosed |