Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | CLK3 | P49761 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25157442 | 0.89 | DYRK1A (0.47) | TDO2ROCK2CDK1CDK2DYRK1A | |
| SCHEMBL30347639 | 0.89 | DYRK1A (0.47) | TDO2ROCK2CDK1CDK2DYRK1A | |
| SCHEMBL25157439 | 0.89 | TDO2 (0.45) | TDO2ROCK2CDC7MAP4K4CCNB2 | |
| SCHEMBL25156980 | 0.85 | TDO2 (0.51) | TDO2ROCK2CDC7MAP4K4CCNB2 | |
| SCHEMBL30347844 | 0.83 | TDO2 (0.55) | TDO2GSK3BDYRK1ACLK2CLK3 | |
| SCHEMBL25156876 | 0.83 | TDO2 (0.55) | TDO2GSK3BDYRK1ACLK2CLK3 | |
| SCHEMBL25519953 | 0.81 | TDO2 (0.51) | TDO2ROCK2DYRK1ACLK2CLK3 | |
| SCHEMBL30407103 | 0.81 | TDO2 (0.47) | TDO2GSK3BDYRK1ACLK2CLK3 | |
| SCHEMBL30348811 | 0.81 | TDO2 (0.47) | TDO2ROCK2GSK3BDYRK1ACLK2 | |
| SCHEMBL25157097 | 0.81 | TDO2 (0.47) | TDO2ROCK2GSK3BDYRK1ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |