Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | IDH1 | O75874 | 5/20 | 0.36 |
| ▸ | IDH2 | P48735 | 4/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30798849 | 1.00 | MALT1 (0.42) | MALT1ALDH1A1CCR1IDH1IDH2 | |
| SCHEMBL25400523 | 0.80 | MALT1 (0.42) | MALT1ALDH1A1IDH1IDH2TAS2R14 | |
| SCHEMBL13306229 | 0.80 | ALDH1A1 (0.39) | ALDH1A1CCR1MPIKMT2AFGFR4 | |
| SCHEMBL29957074 | 0.80 | ALDH1A1 (0.39) | ALDH1A1CCR1MPIKMT2AFGFR4 | |
| SCHEMBL2051841 | 0.72 | — | — | |
| SCHEMBL12151205 | 0.72 | ALDH1A1 (0.47) | ALDH1A1MPIKMT2A | |
| SCHEMBL5261866 | 0.72 | MALT1 (0.39) | MALT1IDH1IDH2 | |
| SCHEMBL4585500 | 0.72 | CCR1 (0.46) | ALDH1A1CCR1MPIKMT2AFGFR4 | |
| SCHEMBL19067019 | 0.71 | KMT2A (0.40) | ALDH1A1MPIKMT2ANOS3NOS2 | |
| SCHEMBL21328933 | 0.70 | MALT1 (0.52) | MALT1IDH1IDH2CYP17A1TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246932-A1 | ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-07-25 | — | — | US | disclosed |
| EP-4334306-A1 | ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2024-03-13 | — | — | EP | disclosed |
| CN-117597339-A | Aryl 3-oxo-piperazine carboxamides and heteroaryl 3-oxo-piperazine carboxamides as NAV1.8 inhibitors | 默沙东有限责任公司 | 2024-02-23 | — | — | CN | disclosed |
| WO-2023171783-A1 | PYRAZOLE COMPOUND, AND NOXIOUS ORGANISM CONTROL AGENT CONTAINING SAME AS ACTIVE INGREDIENT | 三井化学アグロ株式会社 | 2023-09-14 | — | — | WO | disclosed |
| WO-2022235558-A1 | ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2022-11-10 | — | — | WO | disclosed |
| CN-108349983-B | Dihydroimidazopyrazinone derivatives useful for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2021-02-26 | — | — | CN | disclosed |
| US-10202391-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2019-02-12 | — | — | US | disclosed |
| EP-3374359-A1 | DIHYDROIMIDAZOPYRAZINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2018-09-19 | — | — | EP | disclosed |
| US-20180237443-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2018-08-23 | — | — | US | disclosed |
| US-9902731-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2018-02-27 | — | — | US | disclosed |
| US-5580889-A | Insecticidal nitromethyl or niteoimino-heteromethyl-heterocyclics | NIHON BAYER AGROCHEM K.K. (JP) | 1996-12-03 | — | — | US | disclosed |
| US-5461167-A | 2-chloro-5-chloromethyl thiazole; insecticide | NIHON BAYER AGROCHEM K.K. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5428032-A | Insecticides | NIHON BAYER AGROCHEM K.K. (JP) | 1995-06-27 | — | — | US | disclosed |
| US-5298507-A | Insecticides | NIHON BAYER AGROCHEM K.K. (JP) | 1994-03-29 | — | — | US | disclosed |
| US-5204360-A | Insecticides | NIHON BAYER AGROCHEM K.K. (JP) | 1993-04-20 | — | — | US | disclosed |
| US-5001138-A | Insecticides | NIHON TOKUSHU NOYAKU SEIZO, K.K. (JP) | 1991-03-19 | — | — | US | disclosed |
| CN-1047285-A | New phenyl pyrimidine ketone derivatives and preparation method thereof | ICI PLC (GB) | 1990-11-28 | — | — | CN | disclosed |
| US-4845106-A | INSECTICIDES | NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) | 1989-07-04 | — | — | US | disclosed |
| US-4742060-A | 2-(NITROIMINO)- OR 2-(NITROMETHYLENE)-IMIDAZOLIDINES AS INSECTICIDES | NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) | 1988-05-03 | — | — | US | disclosed |
| EP-0192060-A1 | Heterocyclic compounds | NIHON BAYER AGROCHEM K.K. (JP) | 1986-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202391-B2 | Chemical compounds | TP53, RB1, ABCB1 | MALT1 1572/4885ALDH1A1 68/4885CCR1 2023/4885 |
| US-20240246932-A1 | ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS | TRPV1, SCN8A, SCN2A | MALT1 3391/4885ALDH1A1 2844/4885CCR1 962/4885 |
| US-20180237443-A1 | Chemical Compounds | TP53, RB1, ABCB1 | MALT1 1572/4885ALDH1A1 68/4885CCR1 2023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.