Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.67 |
| ▸ | RELA | Q04206 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | BRD4 | O60885 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | CXCR4 | P61073 | 9/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2518679 | 0.96 | KDM4E (0.73) | KDM4EMAPTL3MBTL1GAATP53 | |
| SCHEMBL2525052 | 0.93 | KDM4E (0.76) | KDM4EMAPTL3MBTL1GAATP53 | |
| SCHEMBL2516017 | 0.92 | KDM4E (0.74) | KDM4EMAPTL3MBTL1GAATP53 | |
| SCHEMBL147299 | 0.89 | KDM4E (0.75) | KDM4EMAPTL3MBTL1GAATP53 | |
| Hydrochloric Acid SCHEMBL5594444 | 0.87 | KDM4E (0.73) | KDM4EMAPTL3MBTL1GAATP53 | |
| Hydrochloric Acid SCHEMBL5594440 | 0.87 | KDM4E (0.73) | KDM4EMAPTL3MBTL1GAATP53 | |
| SCHEMBL24716091 | 0.82 | KDM4E (0.97) | KDM4EMAPTL3MBTL1GAATP53 | |
| SCHEMBL30626619 | 0.82 | KDM4E (0.97) | KDM4EMAPTL3MBTL1GAATP53 | |
| SCHEMBL5594566 | 0.81 | KDM4E (0.89) | KDM4EMAPTL3MBTL1GAATP53 | |
| SCHEMBL5594386 | 0.81 | KDM4E (1.00) | KDM4EMAPTL3MBTL1GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324243-B2 | Derivatives of the aminated hydroxyquinoline class for treating cancers | BIOPHARMED (FR) | 2012-12-04 | — | — | US | claimed |
| US-20100120856-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | BIOPHARMED (FR) | 2010-05-13 | — | — | US | claimed |
| US-20130102630-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | BIOPHARMED (FR) | 2013-04-25 | — | — | US | disclosed |
| US-8324243-B2 | Derivatives of the aminated hydroxyquinoline class for treating cancers | BIOPHARMED (FR) | 2012-12-04 | — | — | US | disclosed |
| US-20110251238-A1 | PPAR AGONIST COMPOSITIONS AND METHODS OF USE | BIOPHARMED (FR) | 2011-10-13 | — | — | US | disclosed |
| US-20100120856-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | BIOPHARMED (FR) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120856-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | HNMT, HRAS, NNMT | KDM4E 1395/4885MAPT 4410/4885L3MBTL1 1433/4885 |
| US-20130102630-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | HNMT, NQO1, NQO2 | KDM4E 1779/4885MAPT 4538/4885L3MBTL1 1835/4885 |
| US-20110251238-A1 | PPAR AGONIST COMPOSITIONS AND METHODS OF USE | PPARA, PPARG, PPARD | KDM4E 4239/4885MAPT 4323/4885L3MBTL1 4433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.