Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 17/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25162435 | 0.94 | FGFR4 (0.74) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL25162439 | 0.94 | FGFR4 (0.74) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL25162206 | 0.89 | FGFR4 (0.80) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL27428516 | 0.88 | FGFR4 (0.66) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL25162186 | 0.88 | FGFR4 (0.81) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL28694174 | 0.86 | FGFR4 (0.57) | FGFR4FGFR1FGFR2FGFR3BTK | |
| SCHEMBL25162205 | 0.86 | FGFR4 (0.72) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL30365929 | 0.86 | FGFR4 (0.70) | FGFR4FGFR1FGFR2FGFR3BTK | |
| SCHEMBL15434012 | 0.84 | FGFR4 (1.00) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL28679307 | 0.83 | FGFR4 (0.68) | FGFR4FGFR1FGFR2FGFR3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4393921-A1 | NALIDINONE COMPOUND AS FGFR4 INHIBITOR AND USE THEREOF | Wenzhou Medical University (CN) | 2024-07-03 | — | — | EP | disclosed |
| CN-113912602-B | 2-oxo-1, 2-dihydro-1, 6-naphthyridine-7-yl compound and preparation method and application thereof | 温州医科大学 | 2023-05-05 | — | — | CN | disclosed |
| WO-2023060904-A1 | NALIDINONE COMPOUND AS FGFR4 INHIBITOR AND USE THEREOF | 温州医科大学 | 2023-04-20 | — | — | WO | disclosed |
| CN-113912602-A | 2-oxo-1, 2-dihydro-1, 6-naphthyridine-7-based compound and preparation method and application thereof | 温州医科大学 | 2022-01-11 | — | — | CN | disclosed |