Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.59 |
| ▸ | RAB9A | P51151 | 13/20 | 0.59 |
| ▸ | HPGD | P15428 | 11/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624611 | 0.76 | RAB9A (0.59) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL1852694 | 0.76 | NPC1 (0.59) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL1520979 | 0.72 | RAB9A (0.54) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL18910899 | 0.72 | RAB9A (0.56) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL18470454 | 0.72 | KDM4E (0.54) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL17344108 | 0.72 | KDM4E (0.54) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL28531488 | 0.72 | ALDH1A1 (0.56) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL28975871 | 0.72 | NPC1 (0.54) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL13930840 | 0.71 | RAB9A (0.72) | NPC1RAB9AHPGDKDM4EHSD17B10 | |
| SCHEMBL13930787 | 0.71 | KDM4E (1.00) | NPC1RAB9AHPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9925193-B2 | Thioether derivatives as protein kinase inhibitors | PROQINASE GMBH (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9925193-B2 | Thioether derivatives as protein kinase inhibitors | PROQINASE GMBH (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9925193-B2 | Thioether derivatives as protein kinase inhibitors | PROQINASE GMBH (DE) | 2018-03-27 | — | — | US | disclosed |
| EP-2922857-B1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | PROQINASE GMBH (DE) | 2018-01-03 | — | — | EP | disclosed |
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | PROQINASE GMBH (DE) | 2015-11-19 | — | — | US | disclosed |
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | PROQINASE GMBH (DE) | 2015-11-19 | — | — | US | disclosed |
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | PROQINASE GMBH (DE) | 2015-11-19 | — | — | US | disclosed |
| US-8623111-B2 | Methods for creating a moist top dressing material and products related thereto | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2014-01-07 | — | — | US | disclosed |
| US-20120234219-A1 | Sand Based Fungicides | Board of Regents of Michigan State University | 2012-09-20 | — | — | US | disclosed |
| US-8202343-B2 | Sand based fungicides | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2012-06-19 | — | — | US | disclosed |
| EP-1551835-A1 | NOVEL 1,4-DIAZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE | NeuroSearch A/S (DK) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004029053-A1 | NOVEL 1,4-DIAZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 2004-04-08 | — | — | WO | disclosed |
| US-RE35754-E | FOR TREATING BACTERIAL INFECTIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-24 | — | — | US | disclosed |
| US-5710146-A | ANTIBIOTICS FOR BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| US-5089490-A | Cephem derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-18 | — | — | US | disclosed |
| US-4861787-A | Nematicidal compositions | CIBA-GEIGY CORPORATION (US) | 1989-08-29 | — | — | US | disclosed |
| US-4758556-A | Cephem derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-07-19 | — | — | US | disclosed |
| EP-0263066-A2 | 2-Mercapto-oxadiazole and -thiadiazole derivatives, process for their preparation and nematicides containing them | CIBA-GEIGY AG (CH) | 1988-04-06 | — | — | EP | disclosed |
| US-4713319-A | STORAGE STABILITY; ANTIFOGGING AGENTS; HIGH IMAGE DENSITY; PHOTOTHERMOGRAPHY | FUJI PHOTO FILM CO., LTD. (JP) | 1987-12-15 | — | — | US | disclosed |
| US-4278793-A | ANTIBIOTICS, BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150328219-A1 | THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS | MAP3K1, MAP3K6, MAP3K20 | NPC1 2721/4885RAB9A 2427/4885HPGD 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.