Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 16/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 15/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30329697 | 1.00 | EHMT2 (0.39) | EHMT2EHMT1IGF1RALDH1A1TP53 | |
| SCHEMBL30330171 | 0.93 | EHMT2 (0.40) | EHMT2EHMT1IGF1RALDH1A1 | |
| SCHEMBL25166461 | 0.93 | EHMT2 (0.40) | EHMT2EHMT1IGF1RALDH1A1 | |
| SCHEMBL30329770 | 0.86 | TAAR1 (0.49) | IGF1RALDH1A1TP53MAPTMAPK1 | |
| SCHEMBL25166176 | 0.82 | ALDH1A1 (0.35) | EHMT2EHMT1IGF1RALDH1A1MAPT | |
| SCHEMBL30329732 | 0.82 | ALDH1A1 (0.35) | EHMT2EHMT1IGF1RALDH1A1MAPT | |
| SCHEMBL25166431 | 0.79 | HAVCR2 (0.41) | EHMT2EHMT1IGF1RALDH1A1APOBEC3A | |
| SCHEMBL30330177 | 0.79 | HAVCR2 (0.41) | EHMT2EHMT1IGF1RALDH1A1APOBEC3A | |
| SCHEMBL25166056 | 0.78 | EHMT2 (0.47) | EHMT2EHMT1IGF1R | |
| SCHEMBL25165994 | 0.78 | EHMT2 (0.47) | EHMT2EHMT1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064586-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |