Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 12/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 11/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30330177 | 1.00 | HAVCR2 (0.41) | HAVCR2KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL25166581 | 0.85 | HAVCR2 (0.43) | HAVCR2KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL30329812 | 0.85 | HAVCR2 (0.43) | HAVCR2KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL30329683 | 0.81 | ALDH1A1 (0.39) | HAVCR2KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL25166003 | 0.81 | ALDH1A1 (0.39) | HAVCR2KCNH2KDM4EALDH1A1HPGD | |
| SCHEMBL25166205 | 0.79 | EHMT2 (0.39) | ALDH1A1EHMT2EHMT1APOBEC3AAPOBEC3G | |
| SCHEMBL30329697 | 0.79 | EHMT2 (0.39) | ALDH1A1EHMT2EHMT1APOBEC3AAPOBEC3G | |
| SCHEMBL30329827 | 0.78 | EHMT2 (0.34) | ALDH1A1EHMT2EHMT1APOBEC3AAPOBEC3G | |
| SCHEMBL25166653 | 0.78 | EHMT2 (0.34) | ALDH1A1EHMT2EHMT1APOBEC3AAPOBEC3G | |
| SCHEMBL25166482 | 0.77 | ALDH1A1 (0.38) | HAVCR2KCNH2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064586-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |