Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25171016 | 1.00 | MKNK2 (0.33) | MKNK2KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL30410817 | 1.00 | MKNK2 (0.33) | MKNK2KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL25171015 | 1.00 | MKNK2 (0.33) | MKNK2KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL30309830 | 0.83 | ADORA3 (0.32) | KDM4EHPGDHSD17B10TSHRCASP1 | |
| SCHEMBL25174090 | 0.82 | ALDH1A1 (0.32) | MKNK2KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL30410768 | 0.82 | ALDH1A1 (0.32) | MKNK2KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL25174092 | 0.82 | ALDH1A1 (0.32) | MKNK2KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL25174091 | 0.82 | ALDH1A1 (0.32) | MKNK2KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL25839398 | 0.80 | JAK2 (0.36) | MKNK2KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL25839577 | 0.77 | ALDH1A1 (0.35) | MKNK2KDM4EHPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078267-A1 | AMINO-CONTAINING MACROCYCLIC COMPOUND AS PROTEIN KINASE MODULATOR | 赛诺哈勃药业（成都）有限公司 | 2023-05-11 | — | — | WO | disclosed |