Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.39 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23538393 | 0.81 | DDB1 (0.53) | CYP11B2PDK4NAMPTGRM1GRM5 | |
| SCHEMBL29223716 | 0.80 | SCN9A (0.47) | PDK4NAMPTGRM1GRM5JAK1 | |
| SCHEMBL31323741 | 0.79 | NAMPT (0.45) | CYP11B2PDK4NAMPTGRM1GRM5 | |
| SCHEMBL30952401 | 0.78 | NAMPT (0.47) | PDK4NAMPTGRM1GRM5JAK1 | |
| SCHEMBL30703667 | 0.77 | DDB1 (0.46) | CYP11B2PDK4GRM1GRM5CDK9 | |
| SCHEMBL24319286 | 0.77 | GRM1 (0.47) | CYP11B2PDK4NAMPTGRM1GRM5 | |
| SCHEMBL23120656 | 0.77 | NAMPT (0.52) | PDK4NAMPTGRM1GRM5JAK1 | |
| SCHEMBL31201927 | 0.76 | PDK4 (0.46) | PDK4NAMPTGRM1GRM5JAK1 | |
| SCHEMBL29223732 | 0.76 | PDK4 (0.46) | PDK4NAMPTGRM1GRM5JAK1 | |
| SCHEMBL24607496 | 0.75 | PDK4 (0.52) | CYP11B2PDK4NAMPTGRM1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12559492-B2 | BRAF degraders | C4 THERAPEUTICS, INC. (US) | 2026-02-24 | — | — | US | disclosed |
| US-20230145336-A1 | BRAF DEGRADERS | C4 THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12559492-B2 | BRAF degraders | BRAF, NRAS, HRAS | CYP11B2 2431/4885PDK4 4425/4885NAMPT 4414/4885 |
| US-20230145336-A1 | BRAF DEGRADERS | BRAF, NRAS, RAF1 | CYP11B2 3989/4885PDK4 985/4885NAMPT 656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.