Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2519933 | 0.85 | NOTUM (0.42) | NOTUMTP53CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL6772743 | 0.78 | SMN1; SMN2 (0.43) | TSHRNPC1SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL9487844 | 0.77 | TP53 (0.57) | NOTUMTP53CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL15587224 | 0.74 | MYC (0.47) | ALDH1A1SMN1; SMN2MAPTMYCWDR5 | |
| SCHEMBL28443457 | 0.74 | SMN1; SMN2 (0.45) | TP53ALDH1A1DHFRNPC1SMN1; SMN2 | |
| SCHEMBL9426921 | 0.71 | POLB (0.51) | TP53ALDH1A1HSD17B10DHFRNPC1 | |
| SCHEMBL15362379 | 0.69 | TP53 (0.55) | NOTUMTP53CYP3A4ALDH1A1NPC1 | |
| SCHEMBL9048451 | 0.69 | MYC (0.42) | CYP3A4SMN1; SMN2KDM4EMYCWDR5 | |
| SCHEMBL9098198 | 0.68 | MYC (0.59) | ALDH1A1HSD17B10SMN1; SMN2MAPTMYC | |
| SCHEMBL5171580 | 0.68 | CYP3A4 (0.48) | CYP3A4ALDH1A1TSHRMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034954-B2 | Calcium channel antagonists | ICAGEN, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| EP-1968956-A2 | CALCIUM CHANNEL ANTAGONISTS | Icagen, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| EP-1968596-A2 | CALCIUM CHANNEL ANTAGONISTS | Icagen, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| US-20070197523-A1 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070173504-A1 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| WO-2007075852-A2 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007073497-A2 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173504-A1 | CALCIUM CHANNEL ANTAGONISTS | CACNA1E, CACNA1H, CACNA1G | NOTUM 1993/4885TP53 4365/4885CYP3A4 4717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.