Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2517852 | 0.85 | NOTUM (0.48) | NOTUMTP53CYP3A4DDB1CRBN | |
| SCHEMBL9487844 | 0.78 | TP53 (0.57) | NOTUMTP53CYP3A4DDB1CRBN | |
| SCHEMBL15362379 | 0.70 | TP53 (0.55) | NOTUMTP53CYP3A4DDB1CRBN | |
| SCHEMBL23183158 | 0.69 | TP53 (0.53) | NOTUMTP53CYP3A4DDB1CRBN | |
| SCHEMBL4909473 | 0.67 | TP53 (0.52) | NOTUMTP53CYP3A4DDB1CRBN | |
| 1,3-Diethoxybenzene SCHEMBL1100167 | 0.67 | TP53 (0.71) | TP53CYP3A4ALDH1A1TSHRKMT2A | |
| SCHEMBL1203917 | 0.66 | MAOB (0.60) | TP53CYP3A4ALDH1A1KMT2AMAOB | |
| SCHEMBL19255495 | 0.66 | MAPT (0.45) | ALDH1A1KMT2AMAPTSMN1; SMN2GABRA1 | |
| SCHEMBL12475607 | 0.66 | MAPK1 (0.46) | NOTUMTP53CYP3A4S1PR1ALDH1A1 | |
| SCHEMBL9854197 | 0.65 | KMT2A (0.53) | TP53CYP3A4DDB1CRBNTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034954-B2 | Calcium channel antagonists | ICAGEN, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| EP-1968956-A2 | CALCIUM CHANNEL ANTAGONISTS | Icagen, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| EP-1968596-A2 | CALCIUM CHANNEL ANTAGONISTS | Icagen, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| US-20070197523-A1 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070173504-A1 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| WO-2007075852-A2 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007073497-A2 | CALCIUM CHANNEL ANTAGONISTS | ICAGEN, INC. (US) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173504-A1 | CALCIUM CHANNEL ANTAGONISTS | CACNA1E, CACNA1H, CACNA1G | NOTUM 1993/4885TP53 4365/4885CYP3A4 4717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.