Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.38 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018862 | 0.85 | GRIK1 (0.51) | GRIK1FOLH1TSHRALDH1A1ALOX15 | |
| SCHEMBL3647579 | 0.82 | GRIK1 (0.58) | GRIK1FOLH1TSHRALDH1A1ALOX15 | |
| SCHEMBL547637 | 0.82 | GRIK1 (0.58) | GRIK1FOLH1TSHRALDH1A1ALOX15 | |
| SCHEMBL8487408 | 0.79 | GRIK1 (0.49) | GRIK1FOLH1TSHRALDH1A1ALOX15 | |
| SCHEMBL8486506 | 0.78 | GRIK1 (0.46) | GRIK1FOLH1TSHRALDH1A1ALOX15 | |
| SCHEMBL7298560 | 0.78 | PPM1D (0.53) | GRIK1FOLH1TSHRALDH1A1ALOX15 | |
| SCHEMBL18043819 | 0.73 | CYP2C9 (0.50) | GRIK1FOLH1ALDH1A1GAACYP2C9 | |
| SCHEMBL15058447 | 0.73 | SCN1A (0.50) | GRIK1ALDH1A1CYP2C9 | |
| SCHEMBL2289368 | 0.72 | FOLH1 (0.49) | GRIK1FOLH1TSHRALDH1A1ALOX15 | |
| SCHEMBL10514159 | 0.72 | ALDH1A1 (0.48) | GRIK1ALDH1A1CYP2C9BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034819-B2 | Glucokinase activator | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-10-11 | — | — | US | disclosed |
| US-20100099671-A1 | GLUCOKINASE ACTIVATOR | TEIJIN LIMITED (JP) | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099671-A1 | GLUCOKINASE ACTIVATOR | GCK, GCKR, GALK1 | GRIK1 268/4885FOLH1 2133/4885TSHR 1402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.