Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.74 |
| ▸ | TP53 | P04637 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219122 | 0.86 | POLB (0.72) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL4215477 | 0.85 | TP53 (1.00) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL25192857 | 0.83 | KCNN3 (0.61) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL25199209 | 0.83 | TP53 (0.80) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL4212917 | 0.83 | TP53 (0.80) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL4219187 | 0.82 | TP53 (0.79) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL25187037 | 0.82 | KCNN3 (0.73) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL30421866 | 0.82 | KCNN3 (0.73) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL4218566 | 0.81 | LMNA (1.00) | POLBTP53LMNANPSR1HIF1A | |
| SCHEMBL4207297 | 0.78 | TP53 (0.71) | POLBTP53LMNANPSR1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12312333-B2 | SK channel positive allosteric modulators | CHAPMAN UNIVERSITY (US) | 2025-05-27 | — | — | US | disclosed |
| US-20230159500-A1 | SK CHANNEL POSITIVE ALLOSTERIC MODULATORS | CHAPMAN UNIVERSITY | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159500-A1 | SK CHANNEL POSITIVE ALLOSTERIC MODULATORS | KCNN1, KCNN4, KCNN2 | POLB 3617/4885TP53 4111/4885LMNA 2943/4885 |
| US-12312333-B2 | SK channel positive allosteric modulators | KCNN1, KCNN4, KCNN2 | POLB 3556/4885TP53 4123/4885LMNA 2910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.