Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 15/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 6/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.35 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30411397 | 1.00 | PTK2 (0.44) | PTK2MAP4K1FLT4CAMK2DCCNA2 | |
| SCHEMBL25208797 | 0.89 | MAP4K1 (0.45) | PTK2MAP4K1FLT4CCNA2CDK2 | |
| SCHEMBL30411926 | 0.89 | MAP4K1 (0.45) | PTK2MAP4K1FLT4CCNA2CDK2 | |
| SCHEMBL30412808 | 0.87 | PTK2 (0.40) | PTK2MAP4K1FLT4CCNA2CDK2 | |
| SCHEMBL25204627 | 0.87 | PTK2 (0.40) | PTK2MAP4K1FLT4CCNA2CDK2 | |
| SCHEMBL25202014 | 0.85 | PTK2 (0.42) | PTK2MAP4K1FLT4CCNA2CDK2 | |
| SCHEMBL30412156 | 0.85 | PTK2 (0.42) | PTK2MAP4K1FLT4CCNA2CDK2 | |
| SCHEMBL25224310 | 0.85 | MAP4K1 (0.48) | PTK2MAP4K1 | |
| SCHEMBL30411001 | 0.85 | MAP4K1 (0.48) | PTK2MAP4K1 | |
| SCHEMBL25207838 | 0.83 | LRRK2 (0.39) | PTK2MAP4K1CCNA2CDK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250144094-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. | 2025-05-08 | — | — | US | disclosed |
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250144094-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ULK1, ULK2, ULK3 | PTK2 1123/4885MAP4K1 182/4885FLT4 2240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.