Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | FADS1 | O60427 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2671952 | 0.78 | PDPK1 (0.58) | PDPK1JAK2FADS1DYRK1ACSNK2A1 | |
| SCHEMBL26393980 | 0.77 | GSK3B (0.57) | JAK2DYRK1ACDK2GSK3BAXL | |
| SCHEMBL11748390 | 0.77 | FADS1 (0.54) | FADS1GSK3B | |
| SCHEMBL28079288 | 0.77 | NTRK1 (0.45) | CDK2GSK3BNTRK1GSK3APRKAA1 | |
| SCHEMBL11754096 | 0.76 | TRPA1 (0.50) | PDPK1FADS1FLT3CDK2MAPK8 | |
| Hydrochloric Acid SCHEMBL8487463 | 0.75 | TRPA1 (0.49) | PDPK1FADS1FLT3CDK2MAPK8 | |
| SCHEMBL660142 | 0.75 | PDPK1 (0.58) | PDPK1JAK2FADS1DYRK1ACSNK2A1 | |
| SCHEMBL28079409 | 0.75 | TRPA1 (0.49) | PDPK1FADS1FLT3CDK2MAPK8 | |
| SCHEMBL6487193 | 0.73 | DYRK1A (0.51) | PDPK1JAK2FADS1DYRK1ACSNK2A1 | |
| SCHEMBL15484549 | 0.73 | DYRK1A (0.51) | PDPK1JAK2FADS1DYRK1ACSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078337-A1 | CDK8/19 DUAL INHIBITORS AND METHODS OF USE | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023078337-A1 | CDK8/19 DUAL INHIBITORS AND METHODS OF USE | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-11 | — | — | WO | disclosed |