SCHEMBL25200527

SCHEMBL25200527

CSc1ccc(/C=C/C(=O)c2ccc(C(=O)O)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.77
LMNA P02545 5/20 0.77
KMT2A Q03164 5/20 0.77
MEN1 O00255 3/20 0.77
ALDH1A1 P00352 3/20 0.77
RAB9A P51151 2/20 0.77
GAA P10253 2/20 0.77
CASP3 P42574 1/20 0.77
SENP8 Q96LD8 1/20 0.77
SENP7 Q9BQF6 1/20 0.77
SENP6 Q9GZR1 1/20 0.77
NPC1 O15118 1/20 0.75
NFKB1 P19838 1/20 0.75
HTT P42858 1/20 0.75
NFKB2 Q00653 1/20 0.75
RELA Q04206 1/20 0.75
SMN1; SMN2 Q16637 1/20 0.75
KDM4E B2RXH2 2/20 0.66
NPSR1 Q6W5P4 2/20 0.66
POLB P06746 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28614817 1.00 MAPT (0.77) MAPTLMNAKMT2AMEN1ALDH1A1
SCHEMBL25198689 1.00 MAPT (0.77) MAPTLMNAKMT2AMEN1ALDH1A1
SCHEMBL11815668 0.93 MAPT (0.87) MAPTLMNAKMT2AMEN1ALDH1A1
SCHEMBL9915661 0.93 MAPT (0.87) MAPTLMNAKMT2AMEN1ALDH1A1
SCHEMBL11815663 0.93 MAPT (0.87) MAPTLMNAKMT2AMEN1ALDH1A1
Hydrochloric Acid SCHEMBL11816315 0.92 MAPT (0.84) MAPTLMNAKMT2AMEN1ALDH1A1
Hydrochloric Acid SCHEMBL11816321 0.92 MAPT (0.84) MAPTLMNAKMT2AMEN1ALDH1A1
SCHEMBL658200 0.89 MAPT (0.74) MAPTLMNAKMT2AMEN1ALDH1A1
SCHEMBL9338554 0.89 MAPT (0.74) MAPTLMNAKMT2AMEN1ALDH1A1
SCHEMBL658201 0.89 MAPT (0.74) MAPTLMNAKMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAPT 3297/4885LMNA 1180/4885KMT2A 2792/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885LMNA 1817/4885KMT2A 3188/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885LMNA 1817/4885KMT2A 3188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.