SCHEMBL25201055

SCHEMBL25201055

COc1ccc(C=CC(=O)c2ccc(O)cc2)cc1COc1ccc(F)cc1F

nearest known ligand 0.79

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 9/20 0.79
▸ KMT2A Q03164 9/20 0.79
▸ ALDH1A1 P00352 5/20 0.79
▸ LMNA P02545 4/20 0.79
▸ KDM4E B2RXH2 2/20 0.79
▸ MAPT P10636 3/20 0.73
▸ THRB P10828 1/20 0.73
▸ SMN1; SMN2 Q16637 1/20 0.73
▸ POLB P06746 2/20 0.64
▸ HPGD P15428 1/20 0.64
▸ CTSL P07711 2/20 0.57
▸ CXCL12 P48061 1/20 0.57
▸ ABCG2 Q9UNQ0 1/20 0.53
▸ CA1 P00915 1/20 0.53
▸ CA2 P00918 1/20 0.53
▸ RECQL P46063 1/20 0.53
▸ TUBB1 Q9H4B7 1/20 0.52
▸ CTSB P07858 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31233118 1.00 MEN1 (0.79) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL25234886 1.00 MEN1 (0.79) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL30384740 0.92 MEN1 (0.88) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL25201192 0.92 MEN1 (0.88) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL30384858 0.90 MEN1 (0.76) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL25185030 0.90 MEN1 (0.76) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL30383756 0.88 KMT2A (1.00) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL25191765 0.88 KMT2A (1.00) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL25204454 0.87 MEN1 (0.64) MEN1KMT2AALDH1A1LMNAKDM4E
SCHEMBL30383984 0.87 MEN1 (0.64) MEN1KMT2AALDH1A1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed
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