Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24483586 | 0.90 | EGFR (0.44) | EGFRBCHECYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7049498 | 0.79 | EGFR (0.54) | EGFRDYRK1AALDH1A1NOTUM | |
| SCHEMBL30067519 | 0.79 | EGFR (0.54) | EGFRCYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL24483083 | 0.79 | EGFR (0.54) | EGFRCYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL7049632 | 0.72 | EGFR (0.33) | EGFRDYRK1AALDH1A1TRPA1 | |
| SCHEMBL24483759 | 0.71 | ALDH1A1 (0.48) | EGFRCYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6286885 | 0.71 | EGFR (0.53) | EGFRCYP19A1ALDH1A1NPSR1MAPT | |
| SCHEMBL30067338 | 0.71 | EGFR (0.55) | EGFRCYP19A1ALDH1A1MAPT | |
| SCHEMBL255282 | 0.71 | EGFR (0.55) | EGFRCYP19A1ALDH1A1MAPT | |
| SCHEMBL31061166 | 0.70 | EGFR (1.00) | EGFRADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136582-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2025-05-01 | — | — | US | disclosed |
| CN-119156383-A | Selective KRAS G12C inhibitors and uses thereof | 1200药业有限责任公司 | 2024-12-17 | — | — | CN | disclosed |
| EP-4430035-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 Pharma LLC (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086383-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023086383-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2022240971-A2 | KRAS G12D INHIBITORS AND USES THEREOF | 1200 PHARMA LLC (US) | 2022-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136582-A1 | SELECT KRAS G12C INHIBITORS AND USES THEREOF | KRAS, NRAS, HRAS | EGFR 69/4885BCHE 4830/4885CYP19A1 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.