SCHEMBL25201203

SCHEMBL25201203

COc1ccc(/C=C/C(=O)c2ccc(O)cc2O)cc1CN1CCSCC1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 3/20 0.64
▸ CYP19A1 P11511 1/20 0.63
▸ MAPT P10636 5/20 0.62
▸ ABCG2 Q9UNQ0 4/20 0.62
▸ MEN1 O00255 3/20 0.62
▸ KMT2A Q03164 3/20 0.62
▸ MAPK1 P28482 3/20 0.62
▸ ALDH1A1 P00352 3/20 0.62
▸ TDP1 Q9NUW8 2/20 0.62
▸ TP53 P04637 2/20 0.62
▸ CYP3A4 P08684 2/20 0.62
▸ HPGD P15428 2/20 0.62
▸ ALOX15 P16050 2/20 0.62
▸ ALOX12 P18054 1/20 0.62
▸ KDM4E B2RXH2 3/20 0.60
▸ LMNA P02545 2/20 0.60
▸ NFKB1 P19838 1/20 0.59
▸ NFKB2 Q00653 1/20 0.59
▸ RELA Q04206 1/20 0.59
▸ CTSL P07711 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25199722 0.91 SMN1; SMN2 (0.67) SMN1; SMN2CYP19A1MAPTABCG2MEN1
SCHEMBL25203508 0.89 SMN1; SMN2 (0.81) SMN1; SMN2CYP19A1MAPTABCG2MEN1
SCHEMBL25209738 0.87 MAPT (0.78) SMN1; SMN2MAPTABCG2MEN1KMT2A
SCHEMBL25206731 0.81 CYP19A1 (0.76) SMN1; SMN2CYP19A1MAPTABCG2MEN1
SCHEMBL25199676 0.80 CYP19A1 (0.74) SMN1; SMN2CYP19A1MAPTABCG2MEN1
SCHEMBL25219990 0.79 CYP19A1 (0.72) SMN1; SMN2CYP19A1MAPTABCG2MEN1
SCHEMBL3307506 0.78 CYP19A1 (1.00) SMN1; SMN2CYP19A1MAPTABCG2MEN1
SCHEMBL30383105 0.78 CYP19A1 (1.00) SMN1; SMN2CYP19A1MAPTABCG2MEN1
SCHEMBL25191748 0.78 MAPT (0.83) SMN1; SMN2MAPTABCG2MEN1KMT2A
SCHEMBL3307514 0.78 CYP19A1 (1.00) SMN1; SMN2CYP19A1MAPTABCG2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 — — US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 — — US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 — — US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B SMN1; SMN2 3415/4885CYP19A1 270/4885MAPT 3297/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 SMN1; SMN2 4161/4885CYP19A1 320/4885MAPT 3512/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 SMN1; SMN2 4161/4885CYP19A1 320/4885MAPT 3512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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