SCHEMBL25201619

SCHEMBL25201619

O=C(Cc1ccc2c(c1)OCO2)c1cccs1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.67
CTNNB1 P35222 3/20 0.66
WNT3A P56704 1/20 0.66
LMNA P02545 3/20 0.60
SMN1; SMN2 Q16637 4/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
ALDH1A1 P00352 4/20 0.58
KMT2A Q03164 4/20 0.56
MEN1 O00255 3/20 0.56
PKM P14618 3/20 0.56
TP53 P04637 2/20 0.56
ALOX15 P16050 1/20 0.56
CYP3A4 P08684 2/20 0.55
CYP1A2 P05177 1/20 0.55
CYP2C19 P33261 1/20 0.55
MAPT P10636 4/20 0.54
GAA P10253 3/20 0.54
MAPK1 P28482 2/20 0.54
KDM4E B2RXH2 1/20 0.54
CASP1 P29466 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15969297 0.80 CTNNB1 (1.00) HPGDCTNNB1WNT3ALMNASMN1; SMN2
SCHEMBL1554690 0.77 CTNNB1 (0.66) HPGDCTNNB1WNT3ALMNASMN1; SMN2
SCHEMBL109197 0.76 ALDH1A1 (0.64) HPGDCTNNB1WNT3ALMNASMN1; SMN2
SCHEMBL7148530 0.75 CYP3A4 (0.72) HPGDLMNASMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL25204678 0.75 RAB9A (0.56) HPGDLMNASMN1; SMN2L3MBTL1ALDH1A1
SCHEMBL25222929 0.74 HSD17B10 (0.65) HPGDCTNNB1WNT3ALMNASMN1; SMN2
SCHEMBL25227626 0.74 CTNNB1 (0.67) HPGDCTNNB1WNT3ALMNASMN1; SMN2
SCHEMBL29642680 0.74 CYP3A4 (0.75) HPGDSMN1; SMN2ALDH1A1CYP3A4CYP1A2
SCHEMBL3944098 0.74 CYP3A4 (0.75) HPGDSMN1; SMN2ALDH1A1CYP3A4CYP1A2
SCHEMBL138875 0.74 CYP3A4 (0.75) HPGDSMN1; SMN2ALDH1A1CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4436964-A1 ANALOGUES OF MDMA FOR MODULATING SERT, DAT, AND / OR NET ACTIVITY The University Of Western Australia (AU) 2024-10-02 EP disclosed
WO-2023092195-A1 ANALOGUES OF MDMA FOR MODULATING SERT, DAT, AND / OR NET ACTIVITY THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2023-06-01 WO disclosed
WO-2023092195-A1 ANALOGUES OF MDMA FOR MODULATING SERT, DAT, AND / OR NET ACTIVITY THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2023-06-01 WO disclosed