SCHEMBL25201621

SCHEMBL25201621

COc1ccc(/C=C/C(=O)c2c(O)cccc2OCc2ccccc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.65
APP P05067 1/20 0.63
SLC5A1 P13866 2/20 0.61
SLC5A2 P31639 2/20 0.61
NFKB1 P19838 5/20 0.59
NFKB2 Q00653 5/20 0.59
RELA Q04206 5/20 0.59
ABCG2 Q9UNQ0 2/20 0.59
MAPT P10636 2/20 0.58
TP53 P04637 1/20 0.58
CYP3A4 P08684 1/20 0.58
KMT2A Q03164 1/20 0.58
ATM Q13315 1/20 0.58
HSD17B10 Q99714 1/20 0.58
GSK3B P49841 1/20 0.57
BACE1 P56817 1/20 0.57
CYP2C9 P11712 2/20 0.56
MAOA P21397 2/20 0.56
CYP2C19 P33261 2/20 0.56
CYP19A1 P11511 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16150086 0.92 SLC5A1 (0.72) MAOBAPPSLC5A1SLC5A2NFKB1
SCHEMBL16150089 0.92 SLC5A1 (0.72) MAOBAPPSLC5A1SLC5A2NFKB1
SCHEMBL25190860 0.90 SLC5A1 (0.61) MAOBAPPSLC5A1SLC5A2NFKB1
SCHEMBL25223424 0.90 NFKB1 (0.69) MAOBAPPSLC5A1SLC5A2NFKB1
SCHEMBL25283130 0.90 NFKB1 (0.69) MAOBAPPSLC5A1SLC5A2NFKB1
SCHEMBL1728134 0.90 NFKB1 (0.65) MAOBSLC5A1SLC5A2NFKB1NFKB2
SCHEMBL1728137 0.90 NFKB1 (0.65) MAOBSLC5A1SLC5A2NFKB1NFKB2
SCHEMBL1728224 0.89 NFKB1 (0.61) MAOBAPPSLC5A1SLC5A2NFKB1
SCHEMBL1728221 0.89 NFKB1 (0.61) MAOBAPPSLC5A1SLC5A2NFKB1
SCHEMBL30383381 0.89 NFKB1 (0.61) MAOBAPPSLC5A1SLC5A2NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885APP 794/4885SLC5A1 3752/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885APP 1340/4885SLC5A1 4485/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885APP 1340/4885SLC5A1 4485/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.